The mission of blood banks is to provide safe blood and blood components for safe transfusion to the proper recipients who are suffering from specific blood disorders. To achieve so, a series of technical procedures needed to be performed before the release of blood/ blood components to ensure safe blood donation and transfusion. This course intends to provide the students with the basics of immunohematology principles and applications including blood grouping, pre-transfusion testing, therapeutic approaches, and adverse reactions to blood donation and transfusion.