This course addresses a range of study designs and analytic techniques for observational studies on the utilization, safety, and effectiveness of pharmaceuticals. Students will develop an understanding of how to plan, implement, analyze, and criticize pharmacoepidemiologic studies. Original research will be presented by principal investigators, followed by intensive discussions on design options, analytic strategies, and sensitivity analyses of confounding and misclassification bias. Lectures will provide methodological background and will cover applied issues typically encountered in pharmacoepidemiology.