The aim of this course is to provide students with advanced knowledge of numerous aspects of organic chemistry, as it applies to modern medicinal chemistry. Topics include types and classification of reaction mechanisms with emphasis on some related reactions. Furthermore, the course covers various chemical reactions involving enolates and other carbon nucleophiles, organometallic compounds of group I and II metals as well as transition metals. The course also covers the fundamentals of heterocyclic compounds including properties, synthesis, and reactions of aliphatic and aromatic heterocycles with emphasis on five-membered, six-membered, and fused heterocycle.