This comprehensive pharmacology course emphasizes recent advances in the understanding of pharmacological principles. The course appraises the cellular and molecular biology of signal transduction and will provide a more detailed discussion of the molecular pharmacology of receptors, channels and enzymes. This course will focus also on receptor theory, receptor-ligand interactions, receptors and signal transduction, protein structure-activity relationships, concepts of protein scaffolding and trafficking, genomic regulation of drug action, and pharmacogenomics. Many of these aspects will be reviewed in the context of how defects in such molecular processes produce pathological diseases.