This course provides students with in-depth therapeutic knowledge on the management of different disease conditions in special patients? groups such as the geriatrics, palliative settings and patients in the intensive care unit. It aims at providing students with the pathophysiologic basis, manifestations and management of conditions that require a multidisciplinary and comprehensive approach in the management. It covers a variety of topics such as acute CNS injuries, psychiatric manifestations in the intensive care unit, electrolytes and acid-base derangements, management of diabetic ketoacidosis. Furthermore, the students will be introduced to principles and application of clinical kinetics in the intensive care unit.