This course provides a general introduction to computational tools for biology. The course covers basic concepts in computational biology topics emphasizing in describing basic theoretical concepts of wet-lab experimentation. This course covers different approaches to solve biological problems and several tools to work with DNA and RNA sequence analysis, Sequence databases, Gene expression analysis, Genome assembly, Binding site prediction, Differential equation-based biological models, genome rearrangement. Besides, this lab covers principle methods and tools used for Sequence alignment, Motif finding, and programming skills to implement solutions for the studied problems.