Jordan University of Science and Technology
Comparison of distress and pain in infants randomized to groups
, Wendy Hall, Leslie L. Mill, Scholastica Au, Radhika Bhagat
This randomized controlled trial compared distress and pain in healthy 4-month-old infants
receiving three different immunizations either sequentially (control, n = 50) or simultaneously,
two at the same time, followed by the third (experimental, n = 51). Although both
groups demonstrated a significant increase in cortisol from baseline levels, the lack of significant
difference on salivary cortisol between groups post-immunization suggests the study
was underpowered.OnNIPS scores, the experimental group demonstrated significantly less
pain (Mann?Whitney U= 1648.0, p = 0.003). Simultaneous injections appeared to be effective
in reducing pain behavior responses in infants receiving their 4-month immunizations.
Longitudinal studies could determine whether reduced exposure to pain in infancy, through
simultaneous immunization injections, could contribute to a reduction in sensitivity to pain
and physiologic stress responses.