Abstract:
The pathogenesis of renal diseases associated with Plasmodium malariae
infections is still not fully understood. The present work is concerned with the infection
caused by P. inui in the rhesus monkey Macaca mulatta as a potential model for human
quartan malaria, which the monkey parasite resembles in morphology and schizogonic
behavior. Various aspects of the disease were studied. Changes in the levels of serum
complement components C3 and C4 indicate activation of complement through the clas
sical pathway. A few days after infection, IgG antibody titers increased, coinciding with
low levels of parasitemia, which suggests that some of these antibodies are protective.
Immunofluorescence testing of kidney tissue showed a predominance of 1gM antibodies
over IgG, C3, C4, albumin, and fibrinogen, which was detected in a number of the infected
monkeys. These findings were consistent with those seen in humans with P. malariae
infectionand indicatethatthe P. inui/rhesusmonkey model is likelyto be appropriate for
the study of different aspects of quartan malaria.