Abstract:
Background: Acute kidney injury (AKI) caused by contrast exposure is a common problem,
which may cause a significant increase in patients in-hospital stay and therefore the cost of
treatment. This study was conducted to evaluate the role of inflammation, inflammatory markers
in predicting contrast induced nephropathy (CIN). This is a prospective study that was carried
out in a major tertiary referral hospital in Jordan.
Methods: Clinical data, blood and urine samples were collected from all patients admitted
to the cardiology unit. All patients who agreed to participate in the study had creatinine level
analysis 48?72 hours after the procedure. The CIN was defined as an increase in serum creatinine
by 25% or 44 ?mol/L from the baseline within 48?72 hours after the contrast administration.
Patients with stage 4, 5 renal failure, patients on dialysis, and patients with recent intravenous
contrast use, active infection or cancer were excluded from the study.
Results: Of the total 202 patients, 30 (14.8%) developed CIN. The incidence rate was 21.1%
among females and 12.4% among males. In the multivariate analysis, beside eGFR, diuretics,
and alkaline phosphatase, IL-33 was significantly associated with CIN, while the other cytokines
did not to show this an association.
Conclusion: Serum level of IL-33 was a significant predictor for development of CIN. Good clinical
judgment and high serum levels of IL-33 may stratify patients into low and high risk for CIN.